Journal
FOOD AND CHEMICAL TOXICOLOGY
Volume 68, Issue -, Pages 239-246Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fct.2014.03.020
Keywords
Ganoderma atrum polysaccharide; Antitumor; Apoptosis; Protein kinase A; Protein kinase C
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Funding
- National Key Technology R & D Program of China [2012BAD33B06]
- Key Program of National Natural Science Foundation of China [31130041]
- Program for New Century Excellent Talents in University [NCET-12-0749]
- Research Project of State Key Laboratory of Food Science and Technology [SKLF-ZZA-201301, SKLF-TS-201107]
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Ganoderma atrum polysaccharide (PSG-1) has been commonly suggested as a candidate for prevention and therapy of cancer. We investigated the antitumor effect and the underlying molecular mechanisms of PSG-1. The results showed that PSG-1 inhibited tumor growth and resulted in tumor cell apoptosis in vivo. Here, the data revealed that PSG-1 caused a markedly increase in cAMP and PICA activities, rather than cGMP and PKC. Moreover, the treatment of PSG-1 induced a dramatic increase in the protein level of PICA. In contrast, the expression of PKC and intracellular [Ca2+](i) were inhibited. Our study also revealed that treatment with PSG-1 increased the spleen and thymus weights, lymphocyte proliferation and macrophage phagocytic activity in tumor-bearing mice. Taken together, we conclude that PSG-1 could inhibit the tumor growth, possibly in part by enhancing the induction of apoptosis through cAMP-PICA signaling pathway and down-regulation of Ca2+/PKC signal pathway, activating host immune function in S180-bearing mice. (C) 2014 Elsevier Ltd. All rights reserved.
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