Journal
FOOD AND CHEMICAL TOXICOLOGY
Volume 57, Issue -, Pages 362-370Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fct.2013.04.001
Keywords
Diallyl disulfide; Cell cycle; Apoptosis; Differentiation; Angiogenesis; Invasion
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Funding
- Key Project Foundation of the Science and Technology program of Hunan Province of China [04SK1004]
- Scientific Research Foundation of Hunan Province Education Department of China [04A047, 05C455, 06C694, 06C696]
- National Natural Scientific Foundation of China [30600285, 31000629]
- Hunan Provincial Natural Science Foundation of China [07JJ6155, 07JJ3033]
- Foundation of the Construct Program of the Key Discipline in Hunan Province of China [2006-180]
- University of South China [011XQD60]
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Considerable evidence in recent years suggests that garlic has anti-proliferative effects against various types of cancer. Garlic contains water-soluble and oil-soluble sulfur compounds. Oil-soluble compounds such as diallyl sulfide (DAS), diallyl disulfide (DADS), diallyl trisulfide (DAIS) and ajoene are more effective than water-soluble compounds in protection against cancer. DADS, a major organosulfur compound derived from garlic, can decrease carcinogen-induced cancers in experimental animals and inhibit the proliferation of various types of cancer cells. Its mechanisms of action include: the activation of metabolizing enzymes that detoxify carcinogens; suppression of the formation of DNA adducts; antioxidant effects; regulation of cell-cycle arrest; induction of apoptosis and differentiation; histone modification; and inhibition of angiogenesis and invasion. These topics are discussed in depth in this review. Crown Copyright (C) 2013 Published by Elsevier Ltd. All rights reserved.
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