Journal
FOOD AND CHEMICAL TOXICOLOGY
Volume 58, Issue -, Pages 280-288Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fct.2013.04.050
Keywords
Nano-titanium dioxide; Alloxan; Oxidative stress; Cardiac injury
Categories
Funding
- Major International (Regional) Joint Research Program of China [11120101002]
- National 111 Project of China [B06024]
- China Young 1000-Talent Program
- Shaanxi 100-Talent Program
- Program for New Century Excellent Talents in University [NCET-12-0437]
- International S&T Cooperation Program of China [2013DFG02930]
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Heart diseases, which are related to oxidative stress (OS), negatively affect millions of people from kids to the elderly. Titanium dioxide (TiO2) has widespread applications in our daily life, especially nanoscale TiO2. Compared to the high risk of particulate matter (<= 2.5 mu m) in air to heart disease patients, related research of TiO2 on diseased body is still unknown, which suggest us to explore the potential effects of nanoscale and microscale TiO2 to heart under OS conditions. Here, we used alloxan to induce OS conditions in rat, and investigated the response of heart tissue to TiO2 in healthy and alloxan treated rats. Compared with NMs treatment only, the synergistic interaction between OS conditions and nano-TiO2 significantly reduced the heart-related function indexes, inducing pathological changes of myocardium with significantly increased levels of cardiac troponin I and creatine kinase-MB. In contrast with the void response of micro-TiO2 to heart functions in alloxan treated rats, aggravation of OS conditions might play an important role in cardiac injury after alloxan and nano-TiO2 dual exposure. Our results demonstrated that OS conditions enhanced the adverse effects of nano-TiO2 to heart, suggesting that the use of NMs in stressed conditions (e.g., drug delivery) needs to be carefully monitored. (C) 2013 Elsevier Ltd. All rights reserved.
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