Journal
FOOD AND CHEMICAL TOXICOLOGY
Volume 62, Issue -, Pages 573-578Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fct.2013.09.022
Keywords
Ulvan; Ulva pertusa; Subchronic toxicity; Rats
Categories
Funding
- Natural Science Foundation of China [41206129/D0609]
- Natural Science Foundation of Shandong Province [ZR2012DL13, ZR2010DM010]
- Shandong Province Office of Education [J12LM51]
- Science and Technology Development Project of Shandong Province [2011GHY11529]
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Ulvan extracted from Ulva pertusa (Chlorophyta) is a group of sulfated heteropolysaccharide, for simplicity, the sulfated polysaccharide is referred to as ulvan in this paper. To our knowledge, there is no detailed report investigating the toxicity of ulvan. In this study, the subchronic (6 months) toxicity of varying levels of ulvan extracted from U. pertusa was investigated in Wistar rats after oral administration. ALT, ALB, ALP, WBC, PLT, and liver relative organ weigh of female rats showed significantly difference at 3000 mg/kg body weight per day, compared with control group. On the other hand, TG, T-CHO concentrations of female rats (6 months) were significantly decreased at 600, 1200 and 3000 mg/kg body weight per day. This result proved that ulvan had antihyperlipidemic activity. Beside, ulvan showed anticoagulant activity in this study. Overall, our findings indicated that ulvan had affected specific hematology, serum biochemistry parameters and liver, and had great differences between males and females rats. (C) 2013 Elsevier Ltd. All rights reserved.
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