4.7 Article

Mercury and selenium in fish and shellfish: Occurrence, bioaccessibility and uptake by Caco-2 cells

Journal

FOOD AND CHEMICAL TOXICOLOGY
Volume 50, Issue 8, Pages 2696-2702

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fct.2012.05.028

Keywords

Mercury; Selenium; Seafood; Bioaccessibility; Caco-2 cell; Molar ratio

Funding

  1. Spanish Ministry of Science and Innovation [AGL2005-00619]
  2. Generalitat Valenciana [AE06106]
  3. BANCAJA-CSIC

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This study evaluates Hg and Se concentrations and bioaccessibility (element solubilised after simulated gastrointestinal digestion) in 16 raw seafood species consumed in Spain. The concentrations varied greatly (Hg, 3.8-1621 ng/g wet weight, ww: Se, 84-1817 ng/g ww). Only one sample of swordfish exceeded the Hg limit permitted in Spain (1 mg/kg), and for this sample the Hg/Se molar ratio and Se Health Benefit Value food safety criteria also indicated the presence of a risk. Bioaccessibility of Hg (35-106%) and Se (17-125%) was very variable and the Hg/Se molar ratio in the bioaccessible fraction was less than one for all samples. Transport by Caco-2 cells, an intestinal epithelium model, was also evaluated from the swordfish bioaccessible fraction. Hg and Se transport from the food was less than 14%, and cell retention was much greater for Hg (49-69%) than Se (8-12%). (C) 2012 Elsevier Ltd. All rights reserved.

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