Journal
FOOD AND CHEMICAL TOXICOLOGY
Volume 49, Issue 11, Pages 2734-2740Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fct.2011.08.012
Keywords
HDAC inhibition; [6]-Shogaol; Neuroinflammation; LPS; HSP70
Categories
Funding
- National Research Foundation of Korea
- Korean Government [2010-0007257]
- National Research Foundation of Korea [2010-0007257] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Ginger extracts have been reported to have anti-inflammatory, anti-oxidant, and anti-cancer effects. [6]-shogaol is one of the most bioactive components of ginger rhizomes. This study assessed the [6]-shogaol's ability to protect cultured primary rat astrocytes against lipopolysaccharide (LPS)-induced inflammation. [6]-shogaol was shown to suppress the release of pro-inflammatory cytokines and decreased the level of inducible nitric oxide syntheses (iNOS), cyclooxygenase-2 (COX-2), and phospho-NF-kappa B in LPS-treated astrocytes. Furthermore, [6]-shogaol treatment markedly up-regulated histone H3 acetylation and suppressed histone deacetylase (HDAC)1 expression. In addition, [6]-shogaol treatment also increased the expression of heat-shock protein (HSP)70. The neuroprotective, neurotrphic, and anti-inflammatory properties of [6]-shogaol may be translated to improvements in neurological performance. [6]-Shogaol's ability to inhibit HDAC was comparable to that of commonly used HDAC inhibitors Trichostatin A and MS275. Taken together, our results suggest that [6]-shogaol can significantly attenuate a variety of neuroinflammatory responses by inducing HSP70, that is associated with HDAC inhibition in cortical astrocytes. (C) 2011 Elsevier Ltd. All rights reserved.
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