4.7 Article

Preventive effect of grape seed extract against high-fructose diet-induced insulin resistance and oxidative stress in rats

Journal

FOOD AND CHEMICAL TOXICOLOGY
Volume 48, Issue 7, Pages 1853-1857

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fct.2010.04.021

Keywords

Grape seed extract; Insulin resistance; A high-fructose diet; Oxidative stress

Funding

  1. Ratchadaphisek-somphot Endowment Fund
  2. Graduate School, Chulalongkorn University, Thailand

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The purpose of the present study was to investigate the preventive effect of grape seed extract (GSE) on insulin resistance and oxidative stress in rats fed a high-fructose diet. After 8 weeks of the experiment, the fasting plasma glucose, insulin concentrations, and the homeostasis model assessment of basal insulin resistance (HOMA-IR) of rats fed a high-fructose diet supplemented with 1% GSE were significantly lower than that of a high-fructose diet group. In the oral glucose tolerance test, rats fed a high-fructose diet supplemented with 1% GSE had a significantly reduced plasma glucose and insulin concentrations after 15 min of glucose loading, indicating that GSE improved glucose intolerance. In addition, fed rats fed a high-fructose diet supplemented with 1% GSE markedly increased activity of hepatic superoxide dismutase, catalase, and suppressed lipid peroxidation when compared to rats fed a high-fructose diet. However, rats fed a high-fructose diet supplemented with GSE were not found to have a significant change in the activity of hepatic glutathione peroxidase. In conclusion, intake of GSE may be a feasible therapeutic strategy for prevention of a high-fructose diet-induced insulin resistance and oxidative stress. (C) 2010 Elsevier Ltd. All rights reserved.

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