Journal
FOOD AND CHEMICAL TOXICOLOGY
Volume 48, Issue 12, Pages 3424-3431Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fct.2010.09.015
Keywords
Non-alcoholic steatohepatitis; Oxidative stress; Clerodendron glandulosum .Coleb; HepG2 cells; Oleic acid
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Funding
- University Grants Commission, New Delhi
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This study evaluates the protective role of Clerodendron glandulosum.Coleb (CG) aqueous extract against high fat diet/fatty acid induced lipotoxicity in experimental models of non-alcoholic steatohepatitis (NASH). Supplementation of NASH mice with CG extract (1% and 3% in high fat diet for 16 weeks) prevented high fat diet induced elevation in liver enzymes, plasma and hepatic lipids, mitochondrial oxidative stress and compromised enzymatic and non-enzymatic antioxidant status and histopathological damage to hepatocytes. Furthermore, results from in vitro study indicates, addition of CG extract (20200 mu g/ml for 24 h) to HepG2 cells minimizes oleic acid induced lipid accumulation, higher lipid peroxidation, cytotoxicity and reduced cell viability. These in vivo and in vitro studies suggest that CG extract has the potential of preventing high fat/fatty acid induced NASH. (C) 2010 Elsevier Ltd. All rights reserved.
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