Journal
JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM
Volume 20, Issue 1, Pages 24-31Publisher
WILEY
DOI: 10.1111/jns.12111
Keywords
corneal confocal microscopy; corneal nerves; diabetes; diabetic peripheral neuropathy; obesity
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Funding
- Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development, Biomedical Laboratory Research and Development Service [BX001680-01]
- Rehabilitation Research and Development Service [RX000889-01]
- Iowa City VA Center of Excellence for the Prevention and Treatment of Visual Loss [C9251-C]
- National Institute of Diabetes and Digestive and Kidney Diseases from NIH [DK081147]
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We determined the impact diet-induced obesity (DIO) and types 1 and 2 diabetes have on peripheral neuropathy with emphasis on corneal nerve structural changes in C57Bl/6J mice. Endpoints examined included nerve conduction velocity, response to thermal and mechanical stimuli and innervation of the skin and cornea. DIO mice and to a greater extent type 2 diabetic mice were insulin resistant. DIO and both types 1 and 2 diabetic mice developed motor and sensory nerve conduction deficits. In the cornea of DIO and type 2 diabetic mice there was a decrease in sub-epithelial corneal nerves, innervation of the corneal epithelium, and corneal sensitivity. Type 1 diabetic mice did not present with any significant changes in corneal nerve structure until after 20weeks of hyperglycemia. DIO and type 2 diabetic mice developed corneal structural damage more rapidly than type 1 diabetic mice although hemoglobin A(1)C values were significantly higher in type 1 diabetic mice. This suggests that DIO with or without hyperglycemia contributes to development and progression of peripheral neuropathy and nerve structural damage in the cornea.
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