Journal
FOOD AND CHEMICAL TOXICOLOGY
Volume 48, Issue -, Pages S106-S111Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fct.2009.10.018
Keywords
Sudan I; Margin of exposure; MoE
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Sudan I is generally considered mutagenic based on various in vitro and in vivo tests and is carcinogenic in the rat. Dose-response modelling of the data for hepatocellular adenomas in male rats gave a BMDL(10) of 7.3 mg/kg-bw/day. Sudan I is an unauthorised substance that might be present in food intermittently. The great variability and uncertainties in the human exposure data which are country specific, depending on consumption patterns and methodology used, resulted in a large range of MOE values (from 30 to 2,000,000). (C) 2009 ILSI Europe. Published by Elsevier Ltd. All rights reserved.
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