Journal
FOOD AND CHEMICAL TOXICOLOGY
Volume 47, Issue 6, Pages 1127-1131Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fct.2009.01.037
Keywords
Gardenia jasminoides Ellis; Anti-gastric activity; Genipin; Ursolic acid; Antioxidant; Anti-Helicobacter pylori
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Funding
- Food & Drug Administration, Republic of Korea
- Korea Research Foundation [KRF-2008-005-J00601]
- National Research Foundation of Korea [2008-005-J00601] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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In this study we investigated the effects of Gardenia jasminoides Ellis (GJE) extract and its constituents, such as ursolic acid and genipin, on gastritis in rats and the growth of human gastric cancer cells. The GJE extract, ursolic acid and genipin showed the acid-neutralizing capacities, the antioxidant activities, and the inhibitory effects on the growth of Helicobacter pylon (H. pylori), which are almost equivalent to positive control compounds. In addition, the GJE extract and ursolic acid had cytotoxic activity against AGS and SUN638 gastric cancer cells. The genipin and ursolic acid inhibited significant HCl/ethanol-induced gastric lesions. Taken together, GJE extract and its constituents might have antigastritic activities, associated with the antioxidant activities, acid-neutralizing capacities, and anti-H. pylori action. Also, we could suggest that genipin and ursolic acid may be useful for the treatment and/or protection of gastritis. Crown Copyright (C) 2009 Published by Elsevier Ltd. All rights reserved.
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