Journal
FOOD AND CHEMICAL TOXICOLOGY
Volume 47, Issue 2, Pages 293-297Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fct.2008.11.012
Keywords
Red alga; Laurencia undulata; Asthma; Cytokines; Airway hyperresponsiveness
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Funding
- Korean government (MOST) [R13-2007-023-00000-0]
- Korea Institute of Science & Technology Evaluation and Planning (KISTEP)
- Ministry of Science & Technology (MOST), Korean government, through its National Nuclear Technology Program
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The aim of the present work is focused on protective effects of an edible red alga, Laurencia undulata ethanolic (EtOH) extracts (LU) containing a large amount of polyphenols against OVA-induced murine allergic airway reactions using in vivo histological and cytokine assay. Mice sensitized and challenged with ovalbumin (OVA) showed typical asthmatic reactions as follows: an increase in the number of eosinophil in bronchoalveolar lavage fluid; a marked influx of inflammatory cells into the lung around blood vessels and airways, and airway luminal narrowing: the development of airway hyperresponsiveness; the detection of TNF-alpha and Th2 cytokines, such as IL-4 and IL-5 in the bronchoalveolar lavage (BAL) fluid; and detection of allergen-specific IgE in the serum. The successive intraperitoneal administration of LU before the last airway OVA-challenge resulted in a significant inhibition of all asthmatic reactions. These results suggest that L undulata polyphenolic extracts possess therapeutic potential for combating bronchial asthma associated with allergic diseases. (C) 2008 Elsevier Ltd. All rights reserved.
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