Journal
FOOD AND CHEMICAL TOXICOLOGY
Volume 47, Issue 1, Pages 198-204Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fct.2008.10.029
Keywords
Resveratrol; Oxidative stress; Glaucoma; Trabecular meshwork
Categories
Funding
- Research to Prevent Blindness [NEI EY01894, NEI EY016228, NEI EY014209, NEI EY05722]
- NATIONAL EYE INSTITUTE [K23EY014019, R01EY014209, R01EY001894, P30EY005722, R01EY016228] Funding Source: NIH RePORTER
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Elevated intraocular pressure (IOP) constitutes the best characterized risk for primary open-angle glaucoma (POAG). Elevated IOP is believed to result from an increase in aqueous humor outflow resistance at the level of the trabecular meshwork (TM)/Schlemm's canal. Malfunction of the TM in POAG is associated with the expression of markers for inflammation, cellular senescence, oxidative damage, and decreased cellularity. Current POAG treatments rely on lowering IOP, but there is no therapeutic approach available to delay the loss of function of the TM in POAG patients. We evaluated the effects of chronic administration of the dietary supplement resveratrol on the expression of markers for inflammation, oxidative damage, and cellular senescence in primary TM cells subjected to chronic oxidative stress (40% O-2). Resveratrol treatment effectively prevented increased production of intracellular reactive oxygen species (iROS) and inflammatory markers (IL1 alpha, IL6, 118, and ELAM-1), and reduced expression of the senescence markers sa-p-gal, lipofuscin, and accumulation of carbonylated proteins. Furthermore, resveratrol exerted antiapoptotic effects that were not associated with a decrease in cell proliferation. These results suggest that resveratrol could potentially have a role in preventing the TM tissue abnormalities observed in POAG. (C) 2008 Elsevier Ltd. All rights reserved.
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