Journal
FOOD AND CHEMICAL TOXICOLOGY
Volume 47, Issue 6, Pages 1349-1354Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fct.2009.03.012
Keywords
Catharanthus roseus; Phenolics; Organic acids; Amino acids; Acetylcholinesterase inhibition
Categories
Funding
- Fundacao para a Cienciae a Tecnologia (FCT) [PTDC/AGR-AAM/64150/2006]
- Fundação para a Ciência e a Tecnologia [PTDC/AGR-AAM/64150/2006] Funding Source: FCT
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Catharanthus roseus is nowadays one of the most studied medicinal plants. In this work, further knowledge on different parts of this species (leaves, stems, seeds and petals) was achieved, namely phenolics by HPLC-DAD and organic acids and amino acids by HPLC-UV. Also, the biological potential, expressed as acetylcholinesterase inhibitory activity was accessed and, in some parts, an acetylcholinesterase inhibitory capacity higher than 85% was found (IC50 at 422, 442 and 2683 mu g/mL in leaves, stems and petals, respectively). C. roseus aqueous extract revealed to be a rich source of phenolics, namely caffeoylquinic acids and flavonoids derivatives (up to 4127 mg/kg in stems, 4484 mg/kg in seeds, 8688 mg/kg in leaves and 41125 mg/kg in petals), organic acids (962,6678, 25972 and 12463 mg/kg in seeds, petals, stems and leaves, respectively), such as citric acid (over 85% in some plant parts), and amino acids (31557, 39327, 50540 and 159697 mg/kg in stems, petals, seeds and leaves, respectively), of which arginine was a major compound. (C) 2009 Elsevier Ltd. All rights reserved.
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