Journal
FOOD AND CHEMICAL TOXICOLOGY
Volume 46, Issue 12, Pages 3616-3620Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fct.2008.09.008
Keywords
Andrographolides; Andrographis paniculata; Rats; Urine; Antioxidant status
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Funding
- Ministry of Science and Technology, and Environment, Malaysia
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A simple high-performance liquid chromatography (HPLC) method was developed to determine the content of andrographolide (AP) and 14-deoxy-11, 12-dideoxyandrographolide (DIAP) in a pooled urine of rat obtained within 24 h after an oral dose of Andrographis paniculata leaf extract at 1 g/kg body weight. Cumulative urinary excretion of AP and DIAP in 24 h after oral administration of the extract was 0.88% and 1.61% of oral dose administered, respectively. The extract showed significant reduction (p < 0.05) of MDA levels and elevation of total antioxidant status in rat urine samples collected in 24 after oral administration. (C) 2008 Elsevier Ltd. All rights reserved.
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