Journal
FOOD AND CHEMICAL TOXICOLOGY
Volume 46, Issue 8, Pages 2736-2741Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fct.2008.04.029
Keywords
acute renal injury; ferric-nitrilotriacetate; lipid peroxidation; oxygen free radicals; xanthine oxidase; sesamol
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Funding
- National Science Council, Taiwan [NSC-96-2221-E-006-029-MY3, NSC-96-2314-B-006-012-MY2, NSC-96-2628-B-006038-MY3]
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The aim of this study was to examine the prophylactic protective effects of 3,4-methylenedioxyphenol (sesamol) on ferric-nitrilotriacetate (Fe-NTA)-induced acute renal damage in mice. We induced acute renal injury in mice by treating them with 4 mg/kg of Fe-NTA for 3 h. We used blood biochemistry, creatinine clearance, and histological examinations to assess renal function. With a high-performance chemiluminescence analyzer, we also determined the hydroxyl radical and superoxide anion levels (free radicals) generated. Renal xanthine oxidase activities were also assessed. Sesamol inhibited Fe-NTA-induced acute renal injury, renal lipid peroxidation, the levels of renal hydroxyl radical and superoxide anion generated, and the activity of xanthine oxidase in mice. Therefore, we concluded that sesamol protected mice against Fe-NTA-induced oxidative-stress-associated acute renal injury by at least partially inhibiting the production of reactive oxygen species. (C) 2008 Elsevier Ltd. All rights reserved.
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