Journal
FOOD AND BIOPRODUCTS PROCESSING
Volume 92, Issue C2, Pages 101-112Publisher
ELSEVIER
DOI: 10.1016/j.fbp.2013.05.006
Keywords
Aqueous two-phase system; Continuous extraction; Column contactors; Mixer-settler units
Funding
- Tecnologico de Monterrey Bioprocess Research Chair [CAT161]
- CONACyT [246739, 228073]
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Aqueous two-phase systems (ATPS) have proved to be a suitable technique for the recovery of biological products. Although ATPS have been in the field of primary recovery and purification of products for several years, the majority of the studies exploiting ATPS are usually based on batch mode operation. Reports on the potential of using continuous ATPS are not common. This review attempts to present a practical analysis of selected devices employed for ATPS continuous processing, from the conventional column contactors to novel designed mixer-settler units. A critical analysis of operational and design parameters that impact the system performance is presented. Current trends on the implementation of continuous ATPS approaches are discussed, together with the major challenges faced for the generic adoption of the technique. Conclusions are drawn on the major contribution of previous studies in the field to provide a better understanding of the technique for the newcomers. (C) 2013 The Institution of Chemical Engineers. Published by Elsevier B.V. All rights reserved.
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