Journal
FOOD AND BIOPROCESS TECHNOLOGY
Volume 3, Issue 3, Pages 373-378Publisher
SPRINGER
DOI: 10.1007/s11947-008-0072-z
Keywords
Coculture; Monascus purpureus; Monascus ruber; Lovastatin; Response surface methodology; Solid-state fermentation
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Monascus, fermented rice (red mold rice), has been found to reduce the serum total cholesterol and triglyceride due to presence of lovastatin. Lovastatin acts as an inhibitor of 3-hydroxy-3-methyl glutaryl coenzyme A reductase. Coculture of Monascus purpureus MTCC 369 and Monascus ruber MTCC 1880 was used to produce red mold rice by solid-state fermentation. Optimization of different fermentation process parameters such as temperature, fermentation time, inoculum volume, and pH of the solid medium was carried out by Box-Behnken's factorial design of response surface methodology to maximize lovastatin concentration in red mold rice. Maximum lovastatin production of 2.83 mg/g was predicted at 14th day in solid medium under optimized process condition.
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