Journal
FOOD ANALYTICAL METHODS
Volume 6, Issue 4, Pages 1049-1055Publisher
SPRINGER
DOI: 10.1007/s12161-012-9509-0
Keywords
Capillary electrophoresis; Accelerated solvent extraction; Sulfonamides; Acetylated metabolites; Aquatic products
Categories
Funding
- Natural Science Foundation of Hebei Province [B2008000583]
- sustentation Plan of Science and Technology of Hebei Province [10967126D]
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A rapid and effective method was developed in the first time for the determination of four sulfonamides (SAs) and their N-4-acetylated metabolites in aquatic products using capillary electrophoresis with accelerated solvent extraction (ASE). The eight residues were extracted with acetonitrile at 70 A degrees C under 10.3 MPa pressure and two static cycles with a static time of 5 min. The eight analytes can be baseline separated with 6 min. The standard curves for the determination of eight residues by the capillary electrophoretic method have good linearity (r (2) > 0.999). The method limits of quantification (LOQs) for N-4-acetylsulfadiazine, sulfadiazine, sulfamerazine, sulfamethoxazole, sulfamethazine, N-4-acetylsulfamethazine, N-4-acetylsulfamerazine, and N-4-acetylsulfamethoxazole in aquatic products were 26.4, 33.0, 33.0, 33.0, 39.6, 370, and 1,076 mu g kg(-1), respectively. Intra- and inter-day precision (RSD) were 0.4-2.2 % and 1.4-3.5 %, respectively. Their average recoveries with three spiked levels ranged from 83 % to 116 % with the RSDs less than 4 %. The proposed method provides a rapid and simple extraction procedure with high sensitivity and recoveries, and can permit routine detection of the studied SAs residues in aquatic products at the maximum residue level.
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