Journal
FOOD ANALYTICAL METHODS
Volume 2, Issue 4, Pages 271-281Publisher
SPRINGER
DOI: 10.1007/s12161-008-9066-8
Keywords
Tetracycline; Milk; Europium-Sensitized Luminescence; Screening Method; Validation
Categories
Funding
- Ministero della Salute [IZSLT 09/02]
- CSGI/CNR-FUSINT
- Italian Ministero della Salute
- CSGI (Consorzio Sistemi a Grande Interfase)
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The development of a fast and reliable screening method for the determination of tetracycline residues in milk is described and compared to high-performance liquid chromatography. The method is based on europium-sensitized luminescence: The emissive properties of the lanthanide cation are used as a fingerprint of europium (III) complexation with tetracycline. The optimization of the extraction and purification procedures provided a simple and convenient route to prepare stable tetracycline samples that can safely resist freezing cycles. The method is validated for the first time in milk matrix: The results show that accuracy and precision of the method meet complaints with the criteria of the Commission Decision 2002/657/EC. The proposed method has a false compliant rate (beta error) lower than 5%.
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