Journal
FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT
Volume 29, Issue 8, Pages 1194-1201Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/19440049.2012.692395
Keywords
screening assays; LC/MS; additives general; dietary supplements
Funding
- National '863' Research Foundation of China [2010AA023001]
- National Natural Science Foundation of China aid programme for science and technology innovation research team in higher education institutions of Hunan province [21005027]
- Science Research Foundation of Hunan province [2010TT1001, 05k009]
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Desorption corona beam ionisation (DCBI), the relatively novel ambient mass spectrometry (MS) technique, was utilised to screen for illicit additives in weight-loss food. The five usually abused chemicals - fenfluramine, N-di-desmethyl sibutramine, N-mono-desmethyl sibutramine, sibutramine and phenolphthalein - were detected with the proposed DCBI-MS method. Fast single-sample and high-throughput analysis was demonstrated. Semi-quantification was accomplished based on peak areas in the ion chromatograms. Four illicit additives were identified and semi-quantified in commercial samples. As there was no tedious sample pre-treatment compared with conventional HPLC methods, high-throughput analysis was achieved with DCBI. The results proved that DCBI-MS is a powerful tool for the rapid screening of illicit additives in weight-loss dietary supplements.
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