Journal
FOLIA HISTOCHEMICA ET CYTOBIOLOGICA
Volume 50, Issue 2, Pages 322-324Publisher
VIA MEDICA
DOI: 10.5603/FHC.2012.0043
Keywords
Pseudomonas aeruginosa; aacA4 gene; antimicrobial susceptibility
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The aim of this study was to investigate the prevalence of the aacA4 gene in a population of multidrug resistant strains of P aeruginosa isolated from bronchial secretions obtained from the Intensive Therapy Unit (ITU). Twelve MDR isolates were tested for antibiotic susceptibility and the presence of the aacA4 gene. In this study, 58.3% of the strains contained (6')-Ib' aminoglycoside acetyltransferase gene. All of the studied strains (aacA4-positive and aacA4-negative) were susceptible only to colistine (100%). Among other antibiotics, the lowest resistance rates were those shown against ceftazidime (14.3% to 20%) and imipenem (28.6% to 40%). Our studies frequently revealed the presence of the aacA4 gene as a factor responsible for resistance; it is probable that other mechanisms of resistance to aminoglycoside antibiotics also occurred. (Folia Histochemica et Cytobiologica 2012, Vol. 50, No. 2, 322-324)
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