Journal
FOLIA HISTOCHEMICA ET CYTOBIOLOGICA
Volume 49, Issue 3, Pages 365-374Publisher
VIA MEDICA
DOI: 10.5603/FHC.2011.0052
Keywords
CD163; inflammation
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Mononuclear phagocytes represent a heterogeneous population of cells with individual subpopulations exerting different pro- or anti-inflammatory functions. CD163 is a monocyte/macrophage specific marker expressed predominantly on cells which possess strong anti-inflammatory potential. The expression of CD163 is strongly induced by anti-inflammatory mediators such as glucocorticoids and interleukin-10, while being inhibited by pro-inflammatory mediators such as interferon-gamma. CD163-expressing mononuclear phagocytes, as well as soluble CD163, may both take part in downregulating an inflammatory response. It seems, therefore, that CD163 may be an interesting target for therapeutic modulation of the inflammatory response. (Folic: Histochemica et Cytobiologica 2011, Vol. 49, No. 3, 365-374)
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