Journal
FLY
Volume 4, Issue 3, Pages 182-193Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/fly.4.3.11998
Keywords
signalling; crosstalk; traffic; Notch; Wingless
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Funding
- Wellcome Trust
- Hetchel Smith Fund
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Here we investigate the structural and functional basis of the interactions between Notch and Wingless signalling in Drosophila. Using yeast-two-hybrid and pull-down assays we show that Notch can bind directly a form of Dishevelled that is stabilized upon Wingless signalling. Moreover, we show that the mechanism by which Wingless signalling is able to downregulate Notch is by promoting its ligand-independent traffic to a compartment where it is degraded and that this activity depends on Dishevelled.
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