Journal
FLY
Volume 3, Issue 1, Pages 78-90Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/fly.3.1.7800
Keywords
programmed cell death; apoptosis; reaper; hid; grim; IAPs; caspases; non-apoptotic processes; compensatory proliferation
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Funding
- NIH [R01GM068016, R01GM074977, R01GM081543]
- The Robert A. Welch Foundation [G-1496]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM074977, R01GM068016, R01GM081543] Funding Source: NIH RePORTER
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Programmed cell death, or apoptosis, is a highly conserved cellular process that has been intensively investigated in nematodes, flies and mammals. The genetic conservation, the low redundancy, the feasibility for high-throughput genetic screens and the identification of temporally and spatially regulated apoptotic responses make Drosophila melanogaster a great model for the study of apoptosis. Here, we review the key players of the cell death pathway in Drosophila and discuss their roles in apoptotic and non-apoptotic processes.
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