Journal
JOURNAL OF THE NEUROLOGICAL SCIENCES
Volume 351, Issue 1-2, Pages 168-173Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jns.2015.02.017
Keywords
Angiography; MRI; High-resolution; Varicella zoster virus; Vasculopathy; Treatment
Categories
Funding
- Public Health Service from the National Institutes of Health [AG032958, AG006127]
- NATIONAL INSTITUTE ON AGING [R01AG006127, R37AG006127, P01AG032958] Funding Source: NIH RePORTER
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Contrast-enhanced vessel wall imaging high-resolution MRI (HRMR) has revealed vessel wall thickening and enhancement in multiple intracranial vasculopathies, including varicella zoster virus (VZV) vasculopathy. We retrospectively reviewed a database of patients with virologically-verified VZV vasculopathy, who underwent initial and follow-up HRMR between April 2011 and May 2014. Six patients were identified. Baseline demographic and clinical characteristics were collected, including stroke risk factors, history of VZV-related disorders, neurological presentation, course and antiviral treatment Initial HRMR in patients with VZV vasculopathy demonstrated various patterns of stenosis, vessel wall thickening and enhancement predominantly in terminal internal carotid artery segments and the M1 segment of the middle cerebral arteries. Follow-up HRMR showed improvement of stenosis, with reduced vessel wall thickening and enhancement at multiple times after treatment HRMR has the potential to assist in diagnosis and treatment of VZV vasculopathy. (C) 2015 Elsevier B.V. All rights reserved.
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