Journal
FLUID PHASE EQUILIBRIA
Volume 338, Issue -, Pages 209-216Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fluid.2012.11.029
Keywords
Antibiotic; Tuberculosis; Ionic liquid; Solubility; Phase equilibria; Thermochemical properties
Funding
- Fundacao para a Ciencia e a Tecnologia (FCT, Portugal) [SFRH/BPD/26356/2006, PEst-C/EQB/LA0006/2011]
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A high solubility of antituberculosis antibiotic drugs: isoniazid and pyrazinecarboxamide in ammonium ionic liquids shown in this work, demonstrates the promising perspectives in the drug processing. Solid-liquid equilibrium (SLE) measurements have been made using a dynamic (synthetic) method. Thermophyscial properties such as melting point, enthalpy of fusion, temperatures of phase transitions and corresponding enthalpies for both isoniazid and pyrazinecarboxamide as well as for three ammonium salts were acquired using differential scanning calorimetry (DSC). The solubility of isoniazid in analysed ILs was found to be higher than that of pyrazinecarboxamide. Considering ammonium salts examined in this work, didecyldimethylammonium nitrate is the best solvent for both antibiotics. The solid-liquid phase equilibria were described using six different correlation equations which revealed a relatively good description with an acceptable standard deviation temperature range. (c) 2012 Elsevier B.V. All rights reserved.
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