Journal
FLAVOUR AND FRAGRANCE JOURNAL
Volume 26, Issue 6, Pages 447-451Publisher
WILEY
DOI: 10.1002/ffj.2081
Keywords
carvone; alpha-phellandrene; genotoxicity; monoterpenoids; SMART
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The genotoxicity of 10 essential oil constituents was evaluated using the Drosophila melanogaster (Meigen) somatic mutation and recombination test, also known as the wing spot test, in the frame of a screening project aiming at evaluating the mutagenic activity of widely used substances, natural or not. Of the compounds that we tested here, L-carveol, dihydrocarveol, (+)-dihydrocarvone, (-)-fenchone and (-)-carvyl acetate did not exhibit any mutagenic or recombinogenic activity, whereas (+/-)-linalool, S-(+)-carvone and S-(-)-limonene gave inconclusive results. In contrast, alpha-phellandrene and R-(-)-carvone significantly increased the frequency of mutant spots when compared with the negative control, suggesting mutagenic activity even at the lowest concentration used (1.5 mu l/ml). Moreover, these data clearly demonstrate differences in activity between stereoisomers such as S-(+)- and R-(-)-carvone. Given that alpha-phellandrene and R-(-)-carvone are widely used compounds, further research is needed in order to have a better understanding of their activity and a clearer picture of their genotoxicity in order to decide whether they should remain or not in the lists of compounds that are safe to use. Copyright (C) 2011 John Wiley & Sons, Ltd.
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