Journal
FITOTERAPIA
Volume 95, Issue -, Pages 139-146Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2014.03.013
Keywords
Inula wissmanniana; Asteraceae; Sesquiterpenic acids; RAW264.7 macrophages; NO production
Categories
Funding
- NCET Foundation
- NSFC [81230090, 81102778]
- Global Research Network for Medicinal Plants (GRNMP)
- Shanghai Leading Academic Discipline Project [B906]
- Key Laboratory of Drug Research for Special Environments
- PLA
- Shanghai Engineering Research Center for the Preparation of Bioactive Natural Products [10DZ2251300]
- Scientific Foundation of Shanghai China [10DZ1971700, 12401900501]
- National Major Project of China [2011ZX09307-002-03, 2011ZX09102-006-02]
- National Key Technology R&D Program of China [2012BAI291306]
- 12th Five-Year Plan for Science and Technology Development [2012BAD33805]
- Fundamental Research Funds for the Central Universities [JUSRP1052]
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Eight new (1-8) and two known (9 and 10) sesquiterpenic acids featuring alpha-methylene-gamma-carboxyl units were isolated from the whole plants of Inula wissmanniana, along with two new germacranolides (11 and 12). Their structures were elucidated based on detailed spectroscopic analysis, including HRESIMS, 1D and 2D NMR, and X-ray crystallography. Notably, the skeleton of 1 was firstly discovered from nature, while that of 2 was discovered for the second time. All the compounds were evaluated for their inhibition against LPS-induced nitric oxide (NO) production in RAW264.7 macrophages. Compound 11 exhibited the strongest activity with the IC50 value of 1.04 mu M. (C) 2014 Elsevier B.V. All rights reserved.
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