Journal
FITOTERAPIA
Volume 95, Issue -, Pages 34-41Publisher
ELSEVIER
DOI: 10.1016/j.fitote.2014.02.018
Keywords
Excoecaria acerifolia; Euphorbiaceae; Excoecafolin; Anti-HIV-1; Chemotaxonomy
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Funding
- National Natural Science Foundation of China [31300294]
- Special Fund for Agro-scientific Research in the Public Interest [201303117]
- National Support Science and Technology Subject [2013BAI11804]
- Major Technology Project of Hainan [ZDZX2013008-4, ZDZX2013023-1]
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Three tigliane-type diterpenoids named excoecafolins A-C and two daphnane-type diterpenoids named excoecafolins D and E, together with 13 known compounds, were isolated from the EtOAc extract of Excoecaria acerzfolia Didr. Their structures were elucidated through the analysis of the spectroscopic data. The anti-HIV-1 activity evaluation of five of these compounds showed that four possessed moderate anti-HIV-1 activities with EC50 0.258, 0.036, 0.046, and 0.978 mu M, SI >1,836.9,431.1, 298.7, and >503.7, respectively. Additionally, the chemotaxonomic issue of the affinity correlation between Thymelaeceae and Euphorbiaceae is discussed based on the isolates. (C) 2014 Elsevier B.V. All rights reserved.
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