Journal
FITOTERAPIA
Volume 97, Issue -, Pages 261-267Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2014.06.003
Keywords
Garcinia atroviridis; Clusiaceae; Stem bark; Cholinesterase enzymes inhibitory activity
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Funding
- Universiti Sains Malaysia, Penang [1001/PKIMIA/811129]
- Ministry of Higher Education, Malaysia
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A triflavanone, Garcineflavanone A (1) and a biflavonol, Garcineflavonol A (2) have been isolated from the stem bark of Garcinia atroviridis (Clusiaceae), collected in Peninsular Malaysia. Their structures were established using one and two-dimensional NMR, UV, IR and mass spectrometry and evaluated in vitro for their acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes inhibitory activity. Molecular docking studies of the isolated compounds were performed using docking procedure of AutoDock to disclose the binding interaction and orientation of these molecules into the active site gorge. (C) 2014 Elsevier B.V. All rights reserved.
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