Journal
FITOTERAPIA
Volume 95, Issue -, Pages 115-120Publisher
ELSEVIER
DOI: 10.1016/j.fitote.2014.03.004
Keywords
American cockroach; Periplaneta americana; Isocoumarin; Cytotoxicity
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Funding
- Joint Fund of NSFC-Guangdong Province [U0932004]
- National Natural Science Foundation of China [81172946]
- Program for New Century Excellent Talents in University [NCET-11-0857]
- Science and Technology Planning Project of Guangzhou [2011J2200045, 2011J2200046]
- high-performance computing platform of Jinan University
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Four new isocoumarins (1-4), along with three known ones (5-7), were isolated from the 70% ethanol extract of the whole body of the traditional Chinese insect medicine, American cockroach (Periplaneta americana). The structures with absolute configurations of new compounds were elucidated by extensive spectroscopic methods in combination with X-ray diffraction experiment and CD analyses. Compounds 3-5 showed significant cytotoxic activities in HepG2 and MCF-7 cells with IC50 values in the ranges 6.41-23.91 mu M and 6.67-39.07 mu W, respectively. (C) 2014 Elsevier B.V. All rights reserved.
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