Journal
FITOTERAPIA
Volume 91, Issue -, Pages 224-230Publisher
ELSEVIER
DOI: 10.1016/j.fitote.2013.09.007
Keywords
Excoecaria acerifolia; Euphorbiaceae; Anti-HIV; Diterpenoid; Triterpenoid
Categories
Funding
- Special Fund for Agro-scientific Research in the Public Interest [201303117]
- National Support Science and Technology Subject [2013BAI11B04]
- Fundamental Scientific Research Funds for CATAS [1630052013001, ITBB110301]
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Five new diterpenoids named excocarinols A-E (1-5) including three pimaranes, one cleistanthane, and one nor-beyerane, together with nine known compounds, were isolated from the EtOAc extract of the Chinese ethnodrug Gua-jing-ban (Excoecaria acerifolia Didr.). Their structures were elucidated by the analysis of spectroscopic data including 1D, 2D NMR and HR-MS. The anti-HIV-1 bioassay on the diterpenoids showed that excocarinol A (1) exhibited moderate anti-HIV-1 activity with EC50 5.58 mu M and SI (Selection Index) over 112.71. Crown Copyright (C) 2013 Published by Elsevier B.V. All rights reserved.
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