Journal
FITOTERAPIA
Volume 91, Issue -, Pages 140-147Publisher
ELSEVIER
DOI: 10.1016/j.fitote.2013.08.021
Keywords
Swertia L.; Swertia mussotii; Xanthones; Antioxidant; ORAC
Categories
Funding
- National Natural Science Foundation of China [81172982]
- Guangdong Provincial Project of Science and Technology [2010A030100006]
- State Key Laboratory of Drug Research [SIMM1302KF-12]
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Four new xanthones, 3,5,6,8-tetrahydroxyxanthone-1-C-beta-D-glucoside (1), 7-hydroxy-3,4,8-trimethoxyxanthone-1-O-(beta-D-glucoside) (2), 6-hydroxy-3,5-dimethoxyxanthone-1-O-(beta-D-glucoside) (3), 3,4,7,8-tetramethoxyxanthone-1-O-(beta-D-glucoside) (4), together with twenty-one known xanthones (5-25) were isolated from the ethanol aqueous extract of Swertia mussotii. Their structures were elucidated via spectroscopic analyses. Oxygen radical absorbance capacity of all the isolated xanthones was systematically evaluated by ORAC(FL) assay. Results disclose that all the tested xanthones display moderate to excellent antioxidant activity, where I is the most active compound and 13 is the least one. A preliminary structure-activity relationship is also discussed. (C) 2013 Elsevier B.V. All rights reserved.
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