Journal
FITOTERAPIA
Volume 84, Issue -, Pages 242-247Publisher
ELSEVIER
DOI: 10.1016/j.fitote.2012.12.006
Keywords
Cudrania tricuspidata; Twigs; Phenolic compounds; Tyrosinase inhibitors; Structure-activity relationship study
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Funding
- Innovation and Technology Fund of Hong Kong [ITS/154/09]
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The twigs of Cudrania tricuspidata were found to show strong tyrosinase inhibitory activity, and further detailed component analysis resulted in the isolation of a new flavanol glucoside, (2S,3S)-2, 3-trans-dihydromorin-7-O-beta-n-glucoside (1), plus twenty-seven known compounds (2-28). Their structures were elucidated on the basis of ESI-MS and NMR spectral data. Among the isolated compounds, trans-dihydromorin (8), oxyresveratrol (9), and steppogenin (12) were found to exhibit significant tyrosinase inhibition activities. Moreover, the structure-activity relationship of these isolated compounds was also discussed. (c) 2012 Elsevier B.V. All rights reserved.
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