Journal
FITOTERAPIA
Volume 89, Issue -, Pages 1-7Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2013.04.007
Keywords
Evodia rutaecarpa; Quinolone alkaloids; Antibacterial activity; Cytotoxic activity
Categories
Funding
- National Key Technology R & D Program New Drug Innovation of China [2011ZX09201-201-9, 2012ZX09301002-002-002, 2012ZX09304-005]
Ask authors/readers for more resources
Five new quinolone alkaloids, euocarpines A-E (16-20), four new natural products (1, 4, 12, and 14), and eleven known natural products were isolated from the fruits of Evodia rutaecarpa (Juss.) Benth. The structures of the new compounds were elucidated based on spectroscopic evidence. All compounds were evaluated for their antibacterial activity against three strains and for their cytotoxic activity against four human tumor cell lines. The results revealed that 5, 7-11, 13, 14, and 16-20 exhibited moderate antibacterial activities (MIC values: 4-128 mu g/mL), and 9, 11, 14, and 17 exhibited moderate cytotoxic activities against HepG-2, Hela, BEL7402, and BEL7403 (IC50 values: 15.85-56.36 mu M). Crown Copyright (c) 2013 Published by Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available