Journal
FITOTERAPIA
Volume 85, Issue -, Pages 169-175Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2012.12.005
Keywords
Artemisia argyi; Guaianolide-derived terpenoid; Absolute configuration; Nitric oxide
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Funding
- National Natural Science Foundation of China [30973629]
- National Key Technology R&D Program New Drug Innovation of China [2012ZX09301002-002-002, 2012ZX09304-005]
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An unusual dimeric guaianolide, artemilinin A (1) and a sesquiterpene-monoterpene lactone, isoartemisolide (2), were isolated from the leaves of Artemisia argyi. Their structures were elucidated on the basis of extensive spectroscopic analysis (IR, HR-ES1MS, 1D- and 2D-NMR), and the absolute configurations were determined by CD spectra and quantum chemical ECD calculation. Furthermore, in in vitro assay, compound 2 exhibited pronounced inhibition on the lipopolysaccharide (LPS)-induced nitric oxide (NO) production in BV-2 microglial cells with an IC50 value of 4.00 mu M. (C) 2012 Elsevier B.V. All rights reserved.
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