Journal
FITOTERAPIA
Volume 83, Issue 3, Pages 568-585Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2011.12.028
Keywords
Ginger phenolics; Antioxidant; Cytotoxicity; Neuroprotection; Hepatoprotectant; alpha-Glucosidase; QSAR
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Funding
- High Rank Talents Invited Project [2009CI121]
- Yunnan Science and Technology Department (Modernization of Chinese Technology Industry Base Construction in Yunnan Province) [2008IF012]
- Foundation for the Science and Technology Innovation Team of Yunnan Universities [11]
- Zhejiang University
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Twenty-nine phenolic compounds were isolated from the root bark of fresh (Yunnan) ginger and their structures fully characterized. Selected compounds were divided into structural categories and twelve compounds subjected to in-vitro assays including DPPH radical scavenging, xanthine-oxidase inhibition, monoamine oxidase inhibition, rat-brain homogenate lipid peroxidation, and rat pheochromocytoma PC12 cell and primary liver cell viability to determine their antioxidant and cytoprotective properties. Isolated compounds were also tested against nine human tumor cell lines to characterize anticancer potency. Several diarylheptanoids and epoxidic diarylheptanoids were effective DPPH radical scavengers and moderately effective at inhibiting xanthine oxidase. An enone-dione analog of 6-shogaol (compound 2) was isolated and identified to be most effective at protecting PC12 cells from H2O2-induced damage. Almost all tested compounds inhibited lipid peroxidation. Three compounds, 6-shogaol, 10-gingerol and an enone-diatylheptanoid analog of curcumin (compound 6) were identified to be cytotoxic in cell lines tested, with KB and HL60 cells most susceptible to 6-shogaol and the curcumin analog with IC50<10 mu M. QSAR analysis revealed cytotoxicity was related to compound lipophilicity and chemical reactivity. In conclusion, we observed distinct compounds in fresh ginger to have biological activities relevant in diseases associated with reactive oxygen species. (C) 2012 Elsevier B.V. All rights reserved.
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