Journal
FITOTERAPIA
Volume 83, Issue 3, Pages 518-522Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2011.12.018
Keywords
Laurencia okamurai; Sesquiterpene; Chamigrene; Cuparane; Acetogenin
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Funding
- National Natural Science Foundation of China [41106136, 41106137]
- Shandong Province Natural Science Foundation [ZR2009BQ021]
- Chinese Academy of Sciences for Key Topics in Innovation Engineering [KZCX2-YW-QN209, KZCX2-YW-225]
- Foundation of the Chinese Academy of Sciences
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Three new halogenated sesquiterpenes, 10-bromo-7 alpha,8 alpha-expoxychamigr-1-en-3-ol (1), 10-bromo-beta-chamigren-8-ol (2), and 10-bromo-3-chlorocupar-5-en-2-ol (3), one new C-12-acetogenin, desepilaurallene (7), one new naturally occurring sesquiterpene, 7-hydroxylaurene acetate (4), two known sesquiterpenes, allolaurinterol acetate (5) and laurene (6), and one known C-15-acetogenin, epilaurallene (8), were isolated from the marine red alga Laurencia okamurai collected from the coast of Rongcheng, China. The structures of these compounds were unambiguously established by 1D, 2D NMR and mass spectroscopic techniques. The bioassay results showed that 4,5 exhibited potent antibacterial activity, and 1, 4, 5 were toxic to brine shrimp. (C) 2011 Elsevier B.V. All rights reserved.
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