Journal
FITOTERAPIA
Volume 83, Issue 3, Pages 513-517Publisher
ELSEVIER
DOI: 10.1016/j.fitote.2011.12.016
Keywords
New phenolic constituents; Antifungal activity; Itoa orientalis
Categories
Funding
- National Natural Science Foundation of China [31160375]
- scientific research foundation of Guangxi University [XBZ11382]
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Three new phenolic constituents, itolide A (1), itolide B (2), itoside P (3), and 1D-3-deoxy-3-hydroxymethyl-myo-inositol (4), which is described herein for the first time as a natural product, were isolated along with four other known compounds (5 to 8) from the methanol extract of the seeds of Itoa orientalis Hemsl by the activity-guided fractionation. Their structures were determined by spectroscopic means. Compounds 1 to 8 exhibited antifungal activities against Sclerotium rolfsii with IC50 values ranging from 60.12 to 240.00 mu M and against Rhizoctonia solani with IC50 values ranging from 45.34 to 233.14 mu M, respectively, and compounds 1, 2,5 exhibited cytotoxic activity against Tn5B1-4 insect cell line with EC50 values of 203.68, 93.41 and 40.37 mu M, respectively. (C) 2011 Elsevier B.V. All rights reserved.
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