Journal
FITOTERAPIA
Volume 83, Issue 7, Pages 1238-1241Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2012.06.010
Keywords
Cyclopamine; Peimisine; Chemical conversion; Bamford-Stevens reaction
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Funding
- Ministry of Personnel of the People's Republic of China
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A convenient and efficient one-pot synthesis of cyclopamine from peimisine is described. The key steps involve one-pot hydrazination and subsequent Bamford-Stevens reaction. The mild reaction conditions, high overall yield as well as an easy purification indicate this process can potentially be used for the scale-up preparation of cyclopamine. (c) 2012 Elsevier B.V. All rights reserved.
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