Journal
FITOTERAPIA
Volume 82, Issue 7, Pages 955-959Publisher
ELSEVIER
DOI: 10.1016/j.fitote.2011.05.010
Keywords
Saussurea costus; Asteraceae; Sesquiterpene lactones; Trypanosoma brucei rhodesiense; HPLC-based activity profiling
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Funding
- Directorate General of Higher Education, Department of National Education of Indonesia
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In the course of a larger screen of 1800 plant and fungal extracts, the ethyl acetate extract of Saussurea costus roots potently inhibited the growth of Trypanosoma brucei rhodesiense. Subsequent HPLC based activity profiling led to the identification of the sesquiterpene lactones arbusculin B (1), alpha-cyclocostunolide (2), costunolide (3), and dehydrocostuslactone (4). They were tested for in vitro antitrypanosomal activities and cytotoxicity alongside the structurally related sesquiterpene lactones parthenolide (5), zaluzanin D (6), and eupatoriopicrin (7), and had IC50S between 0.8 and 22 mu M. Cytotoxic IC50S were from 1.6 to 19 mu m, and selectivity indices from 0.5 to 6.5. (C) 2011 Elsevier B.V. All rights reserved.
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