Journal
FITOTERAPIA
Volume 82, Issue 4, Pages 647-653Publisher
ELSEVIER
DOI: 10.1016/j.fitote.2011.02.004
Keywords
Eruca sativa; Isothiocyanates; Melanoma; Apoptosis; UPLC-ESI-MS/MS
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Funding
- MIUR (Rome, Italy)
- BeC s.r.l. (Forli, Italy)
- Department of Science and Technology (New Delhi)
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Solvent extracts from the aerial and root parts and seed oil from E. sativa (rocket salad) were assayed for anticancer activity against melanoma cells. The seed oil (isothiocyanates rich) significantly (p<0.01) reduced the tumor growth comparable to the control. Remarkably, the seed oil inhibited melanoma growth and angiogenesis in mice without any major toxicity. The findings qualify seed oil for further investigations in the real of cancer prevention and treatment. (C) 2011 Elsevier B.V. All rights reserved.
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