Journal
FITOTERAPIA
Volume 82, Issue 8, Pages 1295-1301Publisher
ELSEVIER
DOI: 10.1016/j.fitote.2011.09.003
Keywords
Pogostemonis Herbs; Patchouli alcohol; Anti-inflammatory activity; Xylene; Carrageenan
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Funding
- State Natural Science Funds Commission (NSFC) [u0732004]
- China National Center for Biotechnology Development (CNCBD) [2009ZX09103-376]
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Pogostemonis Herbs has long been used in traditional Chinese medicine for the treatment of inflammatory disorders. Patchouli alcohol (PA), a tricyclic sesquiterpene isolated from Pogostemonis Herba, is known to possess a variety of pharmacological activities. The present study aimed to investigate the in vivo anti-inflammatory effect of PA using two common inflammatory animal models i.e., xylene-induced ear edema in mice and carrageenan-induced paw edema in rats. The degree of edema in both inflammatory animals, as well as the protein and mRNA expression of some inflammatory mediators including tumor necrosis factor-a (TNF-alpha), interleukin-1 beta(IL-1 beta), prostaglandin E-2 (PGE(2)) and nitric oxide (NO) in the hind paw of carrageenan-treated rats were measured. Results showed that PA (10-40 mg/kg) significantly inhibited the ear edema induced by xylene in mice and the paw edema induced by carrageenan in rats. In addition, treatment with PA (10-40 mg/kg) also dose-dependently decreased the production of TNF-alpha, IL-1 beta, PGE(2) and NO in the hind paw of carrageenan-treated rats. Furthermore, PA treatment also suppressed the mRNA expression of TNF-alpha, IL-1 beta, inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in the hind paw of carrageenan-treated rats. These results suggest that PA possesses potent anti-inflammatory activity, which may be mediated, at least in part, by clown-regulating the mRNA expression of a panel of inflammatory mediators including TNF-alpha, IL-1 beta, iNOS and COX-2. (C) 2011 Elsevier B.V. All rights reserved.
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