Journal
FITOTERAPIA
Volume 82, Issue 7, Pages 1062-1074Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2011.07.003
Keywords
Artemisia dracunculus; Wild tarragon; Polyploidy; Germplasm; Diabetes; Sakuranetin
Categories
Funding
- National Center for Complementary and Alternative Medicine (NCCAM) [P50AT002776-01]
- Office of Dietary Supplements (ODS)
- Botanical Research Center of Pennington Biomedical Research Center
- Biotech Center of Rutgers University
- Fogarty International Center [U01TW006674]
- Rutgers University Graduate School
- C. Reed Funk Plant Biology Student Fund
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Ethanolic extracts of diploid Artemisia dracunculus L (wild tarragon) from populations in the U.S., and polyploid tarragon from a variety of sources, were screened for the anti-diabetic compounds davidigenin; sakuranetin; 2',4'-dihydroxy-4-methoxydihydrochalcone; 4,5-di-O-caffeoylquinic acid; 5-O-caffeoylquinic acid and 6-demethoxycapillarisin using LC-MS. Only decaploid plants contained all six target compounds and were the only plants that contained davidigenin and 2,4-dihydroxy-4-methoxydihydrochalcone. These results exhibit the importance of germplasm selection and provenance when studying plants for medicinal activity. Relying only on the right species for consistent medicinal activities may not be sufficient, as intraspecific variation may be highly significant. (C) 2011 Elsevier B.V. All rights reserved.
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