Journal
FITOTERAPIA
Volume 82, Issue 6, Pages 911-919Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2011.05.005
Keywords
Adhesion; Ginsenoside Rh1; Migration; Monocyte; Monocyte attractant protein-1; CCR2
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Funding
- RDA, Republic of Korea [20080101-081-272-001-02-00]
- Ministry of Education, Science and Technology [2011-0018393]
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Ginsenoside Rh1 has been reported to possess antiallergic and anti-inflammatory activities, but its effects on monocytes remain to be determined. Herein, we investigated the effects of Rh1 on the expression of MCP-1 and CCR2, activation of MAPK signaling, and chemotaxis of monocytes. Treatment of Rh1 decreased the levels of MCP-1 and CCR2 and the expression of VLA5 and activated beta 1 integrin on the cell surface, and attenuated the phosphorylation of MAPKs. Based on these results, the inhibitory effects of Rh1 on monocyte function should be regarded as a promising new anti-inflammatory response with a potential therapeutic role against inflammation-dependent diseases. (C) 2011 Elsevier B.V. All rights reserved.
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