Journal
FITOTERAPIA
Volume 82, Issue 4, Pages 654-661Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2011.02.002
Keywords
Antifungal; Anti-inflammatory; Antioxidant; Commiphora erythraea; DPPH; Croton oil test
Categories
Funding
- Comune di Perugia
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The topical anti-inflammatory, free radical scavenging and antifungal activities of essential oils and extracts of Commiphora erythraea (Ehrenb.) Engl. resin were investigated. The hexane extract significantly inhibited oedema when applied topically in Croton oil-induced ear oedema assay in mice. The same extract showed antioxidant activity in DPPH radical scavenging assay. A bioguided separation of the hexane extract led to the isolation of furanosesquiterpenoids 1 and 2 that showed a weak antifungal activity, while compounds 3-5 resulted to be antioxidant (EC(50) 4.28, 2.56 and 1.08 mg/mL, respectively) and anti-inflammatory (30, 26 and 32% oedema reduction, respectively). (C) 2011 Elsevier B.V. All rights reserved.
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