Journal
FITOTERAPIA
Volume 81, Issue 8, Pages 1196-1201Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2010.07.024
Keywords
Honey; Inflammation; Nitric oxide; Prostaglandin; Anti-nociceptive
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Funding
- IPPP by the University of Malaya [PS182/2007B, RG031/09HTM]
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We investigated the effects of honey and its methanol and ethyl acetate extracts on inflammation in animal models. Rats' paws were induced with carrageenan in the non-immune inflammatory and nociceptive model, and lipopolysaccharide (LPS) in the immune inflammatory model. Honey and its extracts were able to inhibit edema and pain in inflammatory tissues as well as showing potent inhibitory activities against NO and PGE(2) in both models. The decrease in edema and pain correlates with the inhibition of NO and PGE(2). Phenolic compounds have been implicated in the inhibitory activities. Honey is potentially useful in the treatment of inflammatory conditions. (C) 2010 Elsevier B.V. All rights reserved.
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