4.6 Article

In vitro TAXOL production, by Pestalotiopsis breviseta - A first report

Journal

FITOTERAPIA
Volume 81, Issue 6, Pages 557-564

Publisher

ELSEVIER
DOI: 10.1016/j.fitote.2010.01.021

Keywords

Taxol; Pestalotiopsis breviseta; LC-MASS; NMR

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Coelomycetous fungi were screened for the production of TAXOL. TAXOL production of Pestalotiopsis breviseta fungi is confirmed by Ultra Violet (UV) spectroscopic analysis, Infra Red (IR) analysis, high performance liquid chromatography (HPLC), nuclear magnetic resonance (NMR) and LC-MASS spectroscopy. TAXOL isolated from the P. breviseta fungus was identical with authentic TAXOL and produces 0.064mg/L (0.128% dry weight of fungal mat). (C) 2010 Elsevier B.V. All rights reserved.

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