Journal
FITOTERAPIA
Volume 81, Issue 8, Pages 1224-1227Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2010.08.006
Keywords
Morus alba; Moraceae; Prenylated flavonoid; Morusin; Cytotoxicity
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Funding
- Vietnam's National Foundation for Science and Technology Development [NAFOSTED-104.01.41.09]
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A phytochemical fractionation of the methanol extract of the Morus alba leaves led to the isolation of eleven flavonoids (1-11). The structure of the new 3'-geranyl-3-prenyl-2',4',5,7-tetrahydroxyflavone (1) was elucidated by means of spectroscopic methods. The cytotoxicity of the isolated compounds against human cervical carcinoma HeLa, human breast carcinoma MCF-7, and human hepatocarcinoma Hep3B cells was evaluated. Of note, morusin (9) was the most potent with an IC(50) value of 0.64 mu M against HeLa cells. (C) 2010 Elsevier B.V. All rights reserved.
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